Our Root 66 South Grand location was the first medical marijuana dispensary to open in the City of St. Louis. South Grand has a flavor all its own. You can travel around the world on South Grand, known locally and regionally as an International District, the neighborhood offers a wide array of activity from unique stores and eclectic shops to a huge array of ethic restaurants.

Root 66 is proud to join the South Grand community and offer patients a wide variety of cannabis products including: cannabis flower, vapes, concentrates, edibles, beverages and more! We pride ourselves on our commitment to the community of South Grand and St. Louis to offer the best experience and widest selection in town.

Root 66 - S Grand (REC)

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We are excited to ELEVATE your disposable game with our brand new line of 0.5g disposable distillate Mini-E-Bars!!


For an easy, on the go, discreet hit!  With it's compact size, the Mini-E-Bar is perfect for anytime, anywhere, and delivers a hit that packs a punch. 


Mac & Cheese - Hybrid - CANNA MIN-E-BAR 500 mg - A labor of love infused with our own in-house cannabis derived terpenes!

Mac & Cheese [500mg]

<p>Cheese, also known as "Dinafem Cheese," is an indica-dominant <a href="/strains/lists/category/hybrid">hybrid</a> marijuana strain from the U.K. named for its sharply sour aroma. Cheese has achieved widespread popularity for its unique flavor and consistent potency. With origins that stretch back to the late 1980s, Cheese is said to descend from a <a href="/strains/skunk-1">Skunk #1</a> <a href="/news/growing/cannabis-genotypes-and-phenotypes-what-makes-a-strain-unique">phenotype</a> whose pungent aroma made it stand out. Breeders like Big Buddha Seeds later introduced <a href="/strains/afghani">Afghani</a> indica genetics to increase Cheese&rsquo;s <a href="/news/cannabis-101/cannabis-anatomy-the-parts-of-the-plant">trichome</a> production and yields. The resulting strain&nbsp;is now well-known for its <a href="/strains/lists/effect/relaxed">relaxed</a>, <a href="/strains/lists/effect/happy">happy</a> effects that gently ease you into a blissful&nbsp;state of mind.</p> 

Cheese, also known as "Dinafem Cheese," is an indica-dominant hybrid marijuana strain from the U.K. named for its sharply sour aroma. Cheese has achieved widespread popularity for its unique flavor and consistent potency. With origins that stretch back to the late 1980s, Cheese is said to descend from a Skunk #1 phenotype whose pungent aroma made it stand out. Breeders like Big Buddha Seeds later introduced Afghani indica genetics to increase Cheese’s trichome production and yields. The resulting strain is now well-known for its relaxed, happy effects that gently ease you into a blissful state of mind.

aroused

creative

energetic

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giggly

happy

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relaxed

sleepy

talkative

tingly

uplifted

Cheese

Named for its sharply sour aroma, Cheese is an indica-dominant hybrid from the U.K. that has achieved widespread popularity for its unique flavor and consistent potency.

Root 66 - S Grand (REC)

Mac & Cheese [500mg]

Mac & Cheese [500mg]

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