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I don't do large hits (I smoke flower - heaping 1/64 teaspoon measure is about right). I always ease into my sessions with smaller hits just in case the strain causes anxiety. Mule Fuel is AWESOME! It's my go-to bedtime strain. Reminds me of G****** Glue in terms of it's ability to sedate and aid sleep. I think I like it better than GG, though. When I get to my 5th or 6th hit it really lays me out. I have to be careful - I can imagine this strain putting me to sleep on my feet. Might be time to do the last hits when I'm already tucked in. That's how powerful its sedating effects are. Anyway, it's a happy, contented oblivion that, like GG, can produce that "Out Of Body" feeling - I lay there feeling like I'm floating without any sense of my body, like my mind is just blissfully floating in space all by its lonesome. Next thing I know, the alarm is chirping and I'm wondering what happened. No recollection of any dreams or other disturbances or interruptions - I fall asleep, sleep deeply, and wake up rested and ready to bounce. LOVE this Mule Fuel!